Professor Xixun Yu, male, born in October 1968, holds a Ph.D. in Engineering and serves as a doctoral supervisor in College of Polymer Science and Engineering, Sichuan University. He obtained his Ph.D. in Biomedical Engineering from Sichuan University in 2002. After completing his postdoctoral research at the West China School of Basic Medical Sciences, Sichuan University in late 2004, he has been engaged in teaching and research at the College of Polymer Science and Engineering, Sichuan University ever since. His primary research interests lie in bone cement, orthopedic repair materials, scaffolds for bone tissue engineering, and soft tissue substitute materials. He possesses extensive experience in the preparation of orthopedic materials, the interaction between materials and cells, and the pretreatment of biological materials derived from animals. Professor Yu teaches three undergraduate courses, including "Biomaterials Evaluation" and four graduate and doctoral courses, such as "Human Anatomy and Physiology". As the project leader or principal investigator, he has undertaken two national key research and development programs, two general programs and one key program funded by the National Natural Science Foundation of China, as well as multiple provincial and municipal projects. He has published over 60 SCI-indexed papers and has been granted or applied for four national invention patents.

Artificial organs, biomaterials, tissue engineering, acellular matrix materials and bone repair materials, etc.

1. Xu Wei, Chang Wan, Xixun Yu*, et al. Copper-based carbon dots modified hydrogel with osteoimmunomodulatory and osteogenesis for bone regeneration. J. Mater. Chem. B 2024, 12: 5734–5748.

2. Yihao Luo, Xu Peng, Xixun Yu*, et al. 3D Molybdenum Disulffde Nanospheres Loaded with Metformin to Enhance SCPP Scaffolds for Bone Regeneration. ACS Appl. Mater. Interfaces 2024, 16: 201−216.

3. Mengyue Hu, Shubin Shi, Xixun Yu*, et al. A synergistic strategy of dual-crosslinking and loading intelligent nanogels for enhancing anti-coagulation, pro-endothelialization and anti-calcification properties in bioprosthetic heart valves. Acta Biomaterialia 2023, 171: 466–481.

4. Ningning Lei, Xu Peng, Xixun Yu*, et al. Research on essential performance of oxidized chitosan-crosslinked acellular porcine aorta modified with bioactive SCPP/DOPA for esophageal scaffold with enhanced mechanical strength, biocompatibility and anti-inflammatory. International Journal of Biological Macromolecules 2023, 241: 124522.

5. Mengyue Hu, Xu Peng, Xixun Yu*, et al. Dialdehyde xanthan gum and curcumin synergistically crosslinked bioprosthetic valve leaflets with anti-thrombotic, anti-inflammatory and anti-calcification properties. Carbohydrate Polymers 2023, 310: 120724.

6. Can Cheng, Xu Peng, Xixun Yu*, et al. A photocrosslinked methacrylated carboxymethyl chitosan/oxidized locust bean gum double network hydrogel for cartilage repair. J. Mater. Chem. B 2023, 11: 10464–10481.

7. Ningning Lei, Xu Peng, Xixun Yu*, et al. Cascade Regulation of the Proliferation, Recruitment, and Differentiation of Stem Cells to Prevent Aseptic Loosening by GNPs/ECPP Particles Responding to Macrophages: In Vitro and In Vivo. ACS Biomater. Sci. Eng 2023, 9: 2452−2469.

8. Xiaoshuang Yu, Pengfei Yue, Xixun Yu*, et al. A dural substitute based on oxidized quaternized guar gum/porcine peritoneal acellular matrix with improved stability, antibacterial and anti-adhesive properties. Chinese Chemical Letters 2023, 34: 107591.

9. Can Cheng, Xu Peng, Xixun Yu*, et al. Feasibility study of oxidized naringin as a novel crosslinking agent for crosslinking decellularized porcine A chilles tendon and its potential application for anterior cruciate ligament repair. Journal of Biomedical Materials Research Part A 2023, 111: 170-184.

10. Chang Wan, Mengyue Hu, Xixun Yu*, et al. Novel multifunctional dexamethasone carbon dots synthesized using the one-pot green method for anti-inflammatory, osteogenesis, and osteoimmunomodulatory in bone regeneration. Biomaterials Science 2022, 10: 6291–6306.

11. Mengyue Hu, Xu Peng, Xixun Yu*, et al. Well-designed two-fold crosslinked biological valve leaflets with heparin-loaded hydrogel coating for enhancing anticoagulation, endothelialization, and anticalcification. Biomaterials Science 2022, 10: 5535-5551.

12. Xu Wang, Yaping Wang, Xixun Yu*, et al. Feasibility study of the naturally occurring dialdehyde carboxymethyl cellulose for biological tissue fixation. Carbohydrate polymers 2015, 115: 54-61.

13. Xu Wang, Zhipeng Gu, Xixun Yu*, et al. Crosslinking effect of dialdehyde starch (DAS) on decellularized porcine aortas for tissue engineering. International Journal of Biological Macromolecules 2015, 79: 813-821.

14. Yuanting Xu, Chengcheng Huang, Xixun Yu*, et al. In vitro enzymatic degradation of a biological tissue fixed by alginate dialdehyde. Carbohydrate polymers 2013, 95: 148-154.

15. Yuanting Xu, Li Li, Xixun Yu*, et al. Feasibility study of a novel crosslinking reagent (alginate dialdehyde) for biological tissue fixation. Carbohydrate polymers 2012, 87: 1589-1595.