2012.10- 2016.03    Max Planck Institute for Polymer Research   Mainz, Germany

Doctor’s degree in natural science (Supervisor: Prof. Hans-Juergen Butt)

2009.09-2012.07    Jilin University Changchun, China

Master’s degree in Polymer chemistry and physics (Supervisor: Prof. Bai Yang and Prof. Junhu Zhang)

2005.09-2009.07    Jilin University   Changchun, China

Bachelor’s degree in Polymer materials and engineering

2018.05- today     Sichuan University  Chengdu, China

Associate Professor, Doctoral supervisor major in biomedical engineering

2016.07-2018.05   Sichuan University  Chengdu, China

Assistant Professor

l Osteoarthritis treatment

Ø Mimicking the activities of metabolic enzymes and synthetases, we design zwitterionic nanozyme to enhance lubrication, activate heat shock response, and promote hyaluronic acid synthesis, facilitating the restoration of osteoarthritic cartilage.

Ø Addressing lubrication failure and sustained drug release within the articular cartilage, we designed a ring brush topology structure based on zwitterionic polymers. This innovative approach achieves a state of superlubricity (COF=0.017) through cooperative lubrication.

Ø Developing a cartilage-targeting zwitterion polymer inspired by lubricant molecules.

l Osteoporosis treatment

Ø Developing peptide-modified injectable SiO₂ nanoparticles, aiming to enhance the stability and prolong the therapeutic effect of sCT.

Ø Designing a series of injectable thermosensitive hydrogels based on natural polysaccharides to extend the release period of sCT for over 28 days and significantly enhance osteogenic activity by two-fold.

Ø Conducting a comprehensive review on the spatiotemporal controlled release system of sCT in OP treatment, emphasizing its crucial role in the management of bone and joint diseases.

l Bone (Osteochondral) defect repair

Ø Designing a double-layer hydrogel with strong interface binding force to simulate cartilage/bone, which can realize vascularization of osteochondral defects in 4 weeks and complete osteochondral healing in 8 weeks.

Ø Preparing injectable hydrogel with antibacterial and osteogenic properties, which can be used for bone defects in refractory periapical periodontitis.

1. Miao Zhang, Xu Peng, Hong Xu, Xiaoning Sun, Yizhu Liu, Qian Li, Yuan Ding, Shaopei Ding, Jun Luo, Jing Xie*, Jianshu Li* Photoacoustic Imaging-Guided Self-Adaptive Hyperthermia Supramolecular Cascade Nano-Reactor for Diabetic Periodontal Bone Regeneration Adv. Sci. 2024, 11, 2404143

2. Peng Yu, Xu Peng, Hui Sun, Qiangwei Xin, Han Kang, Peng Wang, Yao Zhao, Xinyuan Xu, Guangwu Zhou, Jing Xie* and Jianshu Li * Inspired by lubricin: a tailored cartilage-armor with durable lubricity and autophagy-activated antioxidation for targeted therapy of osteoarthritis Mater. Horiz. 2024, DOI: 10.1039/D4MH00812J

3. Peng Yu, Yanyan Li, Hui Sun, Hongbo Zhang, Han Kang, Peng Wang, Qiangwei Xin, Chunmei Ding, Jing Xie* and Jianshu Li* Mimicking Antioxidases and Hyaluronan Synthase: A Zwitterionic Nanozyme for Photothermal Therapy of Osteoarthritis Adv. Mater. 2023, 2303299

4. Miao Zhang, Xu Peng, Yuan Ding, Xiang Ke, Kai Ren, Qiangwei Xin, Meng Qin, Jing Xie* and Jianshu Li* A cyclic brush zwitterionic polymer based pH-responsive nanocarrier-mediated dual drug delivery system with lubrication maintenance for osteoarthritis treatment Mater. Horiz. 2023, 10, 2554

5. Shuaibing Wang, Kai Ren, Miao Zhang, Luxuan Shen, Guangwu Zhou, Yuan Ding, Qiangwei Xin, Jun Luo, Jing Xie*, and Jianshu Li* Self-Adhesive, Strong Antifouling, and Mechanically Reinforced Methacrylate Hyaluronic Acid Cross-Linked Carboxybetaine Zwitterionic Hydrogels Biomacromolecules 2024, 25, 474−485

6. Peng Yu, Yanyan Li, Hui Sun, Xiang Ke, Jiaqi Xing, Yiran Zhao, Xinyuan Xu, Meng Qin, Jing Xie*, Jianshu Li* A Cartilage-inspired Hydrogel with Mechanical Adaptability, Controllable Lubrication and Inflammation Regulation Abilities ACS Appl. Mater. Interfaces, 2022, 14, 27360.

7. Jiaqi Xing, Yuan Ding, Xiaoran Zheng, Peng Yu, Meng Qin, Rongmin Qiu, Yanyan Li, Siyuan Shang, Jing Xie*, Jianshu Li* Barnacle-Inspired robust and aesthetic Janus patch with instinctive wet adhesive for oral ulcer treatment Chem. Eng. J. 2022, 444, 136580

8. Kai Ren, Xiang Ke, Zhu Chen, Yao Zhao, Lu He, Peng Yu, Jiaqi Xing, Jun Luo, Jing Xie*, Jianshu Li* Zwitterionic polymer modified xanthan gum with collagen II-binding capability for lubrication improvement and ROS scavenging Carbohydr. Polym. 2021, 274, 118672

9. Peng Yu, Yanpeng Liu, Jing Xie*, Jianshu Li* Spatiotemporally controlled calcitonin delivery: Long-term and targeted therapy of skeletal diseases J. Controlled Release 2021, 338, 486

10. Jiaqi Xing, Xu Peng, Anqi Li, Meilin Chen, Yuan Ding, Xinyuan Xu, Peng Yu, Jing Xie*, Jianshu Li* Gellan gum/alginate-based Ca-enriched acellular bilayer hydrogel with robust interface bonding for effective osteochondral repair Carbohydr. Polym. 2021, 270, 118382

1. member of the Materials Horizons Community Board

2. Outstanding Guidance Teacher for Innovation, Entrepreneurship, and Practical Education for College Students at Sichuan University

3. the Third Prize in the 12th China College Student Polymer Materials Innovation and Entrepreneurship Competition