张凌，男，博士，四川大学高分子科学与工程学院研究员，医用高分子材料系（生物医学工程方向）成员。2006年本科毕业于复旦大学生物科学专业；2011年于英国曼切斯特大学生命科学学院获细胞生物学博士学位。2011至2018年任英国曼切斯特大学生命、健康与医学学院Research Assistant/Associate，主要从事细胞内吞转运和内吞体运输必需分选复合物（ESCRT）通路研究。2018年入职四川大学高分子科学与工程学院。参与获得国家科学技术进步奖二等奖。国家自然科学基金“优秀青年人才”项目获得者、四川省学术带头人后备人选、“天府峨眉计划”青年人才、成都市蓉漂人才。工作主要涉及高分子与生物学交叉领域，包括材料-生物相互作用机理及后续生物效应、小体积材料的跨膜运输和信号、新型药物传递材料、新型医疗用材料、高分子及纳米材料的毒性研究等等。此外，对生物信息学、计算数学、生物物理等学科在相关研究中的应用也有浓厚兴趣。与华西医院、华西第四医院、华中同济、川大计算机、中科院植物所等多个单位开展深入合作。
近年在Nat. Nanotechnol.、Sci. Adv.、Nat. Commun.、Signal. Transduct. Target. Ther.、Adv. Mater.、Adv. Fiber Mater等杂志上以第一作者或通讯作者发表论文60余篇。以第一发明人获授权中国发明专利15项，转让4项，转化总金额3000余万元；目前正积极开展医疗器械等产品的转化开发工作。
研究方向：
1. 高分子等材料与生物系统微观相互作用
2. 脂质体及其他纳米材料递送系统
3. 微材料的跨膜运输以及跨膜信号系统
4. 结合组学、数学模型等的生物-纳米系统研究
常年招聘材料、生物、医药、数学、物理、计算机背景的研究生（包括各种联合培养形式）和博后，同时欢迎四川大学各学科背景的本科同学，以及成都地区其他院校本科生到实验室做毕业论文或利用业余时间从事科研项目。此外，我们将为课题组成员以后的留学、出国交流及保研等方面尽量提供推荐和帮助。欢迎感兴趣的同学与我直接联系。邮箱: zhangling83@scu.edu.cn，地址：四川大学望江校区高分子学院主楼405。
2021年以来发表论文：
1．Jing Li, Zeyan Li, Qixue Bao, Yuling Chen, Mengxing Zhang, Run Tian, Xitong Yang, Zhenmi Liu, Yuqin Yao, Qing Lin, Zhirong Zhang, Lin Li*,Ling Zhang*. Polystyrene nanoplastics readily penetrate intestine and cause sex-specific effects mediated by bile acids and microbiome. Cell Reports, 2026, 45(2).
2．JiaxiHan1, Taotian Zhang1,Yilin Jiang, Tianyuan Che, Jiawei lu, Zhenkang Diao, Shiqi Huang*, Ling Zhang*.A Lung-Targeted Self-Assembled Supramolecular nanofiber for Synergistic Therapy of Idiopathic Pulmonary Fibrosis. Nanoscale, 2026.
3．Shanshan He, Xiaoyang Li, Yuanyuan He, Ling Guo, Yunzhou Dong, Leilei Wang, Lan Yang, Lin Li, Shiyun Huang, Jiali Fu, Qing Lin, Zhirong Zhang, Ling Zhang*. High-density lipoprotein nanoparticles spontaneously target to damaged renal tubules and alleviate renal fibrosis by remodeling the fibrotic niches. Nature Communications, 2025, 16(1): 1061.
4．Yikun Han1, Shuhao Zhou1, Honglin Xiang, Qiang Zhang, Hanming Zhang, Yicong Zhang, Qing Lin, Zhirong Zhang, Ling Zhang*, Shiqi Huang*. A brain-targeting dl-3-n-butylphthalide prodrug to treat ischemic stroke. European Journal of Medicinal Chemistry, 2025, 290: 117474.
5．Haozhou Shu, Taotian Zhang, Yilin Jiang, Zhenkang Diao, Yani Xu, Jiaying Long,Tianyuan Chen, Mengxing Zhang, Zhirong Zhang, Junjie Chen, Shiqi Huang*, Ling Zhang*. Mechanoregulative hydrogel facilitates rapid scarless healing by self-adaptive control of wound niche at different stages. Science Advances, 2025, 11(21): eadv9895.
6．Jiaying Long, Yicong Zhang, Mengxing Zhang, Zhenkang Diao, Taotian Zhang, Hanming Zhang, Qing Lin, Tao Gong, Xun Sun, Zhirong Zhang, Shiqi Huang*, Ling Zhang*. Delivery of NK cells in an injectable dynamic hydrogel effectively remodels tumor microenvironment and inhibits post-surgery tumor recurrence. Chemical Engineering Journal, 2025: 163507.
7．Yunzhen Gao, Na Jia, Yi Liang, Yani Xu, Rongying Shi, Jiaying Long, Qing Lin, Zhirong Zhang, Ling Zhang*, Shiqi Huang*. Targeted delivery of sinomenine hydrochloride using recombinant ferritin nanocages for rheumatoid arthritis treatment. Nanoscale, 2025, 17, 16025-16038.
8．Jialan Tang, Haozhou Shu, Jiawei Lu, Taotian Zhang, Shiqi Huang* , Ling Zhang*. Highly Stretchable and Conductive Liquid Metal-Reinforced Interpenetrating Polymer Network Hydrogel for Wearable Devices. Polymer, 2025: 128825.（本科生独立一作）
9．Na Jia, Yunzhen Gao, Lan Yang, Yani Xu, Zhirong Zhang, Jingwen Wang*, Ling Zhang*. Precise Control of the in vivo Fate of Nanomicelles Efficiently Treats Advanced Rheumatoid Arthritis via EGFR/JNK/MMP9 Pathway. International Journal of Nanomedicine, 2025: 5353-5375.
10．Lan Yang, Yongshun Zhang, Tianyuan Chen, Jiaxi Han, Hairui Wang, Mengxing Zhang, Qixue Bao, Zhenkang Diao, Taotian Zhang, Yilin Jiang, Shiqi Huang, Ling Zhang*. Dual Targeting Biomimetic Nanoplatform Eradicates Oncogenic Bacteria While Reinvigorating Anti-Tumor Immunity in Breast Cancer. ACS Applied Materials & Interfaces, 2025, 17, 44, 60319–60331.
11．Jingxin Xu, Mingjun Wu, Jie Yang, Dezhang Zhao, Dan He, Yingju Liu, Xiong Yan, Yuying Liu, Daojun Pu, Qunyou Tan*, Ling Zhang*, Jingqing Zhang*. Multimodal smart systems reprogramme macrophages and remove urate to treat gouty arthritis. Nature Nanotechnology, 2024, 19(10): 1544-1557.
12．Yani Xu, Lan Yang, Min Li, Haozhou Shu, Na Jia, Yunzhen Gao,Rongying Shi, Xiaojia Yang, Zhirong Zhang, and Ling Zhang*. Anti-osteosarcoma trimodal synergistic therapy using NiFe-LDH and MXene nanocomposite for enhanced biocompatibility and efficacy. Acta Pharmaceutica Sinica B, 2024, 14(3), 1329-1344.
13．Leilei Wang, Shanshan He, Rong Liu, Yuan Xue, Yuan Quan, Rongying Shi, Xueying Yang, Qing Lin, Xun Sun, Zhirong Zhang, and Ling Zhang*. A pH/ROS dual-responsive system for effective chemoimmunotherapy against melanoma via remodeling tumor immune microenvironment. Acta Pharmaceutica Sinica B, 2024.
14．Mengxing Zhang, Jing Li, Na Ji, Qixue Bao, Ningyun Sun, Hongding Rong, Xu Peng, Lan Yang,Mingxin Xie, Shanshan He, Qing Lin, Zhirong Zhang, Lin Li*, and Ling Zhang*. Reducing cholesterol level in live macrophages improves delivery performance by enhancing blood shear. Nano Letters, 2024, 24(2), 607-616.
15．Yicong Zhang, Yujia Wang, Hanming Zhang, Shiqi Huang, Yuai Li, Jiaying Long, Yikun Han, Qing Lin, Tao Gong, Xun Sun, Zhirong Zhang, and Ling Zhang*. Replacing cholesterol with asiatic acid to prolong circulation and enhance anti-metastatic effects of non-PEGylated liposomes. Journal of Controlled Release, 2024, 366, 585-595.
16．Hanming Zhang, Honglin Gao,Yicong Zhang,Yikun Han,Qing Lin, Tao Gong, Xun Sun, Zhirong Zhang, Ling Zhang*, Shiqi Huang*. Enzyme-activatable disk-shaped nanocarriers augment tumor permeability for breast cancer combination therapy. Nano Research, 2024, 17(7): 6400-6410.
17．Wenjing Liu, Rong Zhang, Gaigai Duan, Ling Zhang*, Yiwen Li*, Lei Yang*. Bio-inspired and Multifunctional Polyphenol-Coated Textiles. Advanced Fiber Materials, 2024, 6(4): 952-977.
18．Jiaxi Han, Haozhou Shu, Ling Zhang*, and Shiqi Huang*. Latest advances in hydrogel therapy for ocular diseases. Polymer, 2024, 306: 127207.
19．Zhaojie Zhou1,Jiaxi Han1, Puxin Lang, Mengxing Zhang, Haozhou Shu, Ling Zhang*, and Shiqi Huang*. ROS-responsive self-assembly nanoplatform overcomes hypoxia for enhanced photodynamic therapy.Biomaterials Science, 2024, 12, 5105-5114.
20．Shiqi Huang, Hanming Zhang, Yicong Zhang, Luyao Wang, Zhirong Zhang, and Ling Zhang*. Comparison of two methods for tumour-targeting peptide modification of liposomes. Acta Pharmacologica Sinica, 2023, 44(4): 832-840.
21．Qiang Zhang, Yikun Han, Honglin Xiang, Min Li, Lan Yang, Qiang Liu, Yan Zhang, Zhirong Zhang, Qing Lin*, and Ling Zhang*. Biopharmaceutical, preclinical pharmacokinetic and pharmaco-dynamic investigations of an orally administered novel 3-nbutylphthalide prodrug. European Journal of Pharmaceutical Sciences, 2023,180: 106308.
22．Puxin Lang, Tiantian Liu, Shiqi Huang, Zhaojie Zhou, Mengxing Zhang, Yunzhu Lin, Qin He, Yuqin Yao, Zhenmi Liu*, and Ling Zhang*. Degradable Temperature-Sensitive Hydrogel Loaded with Heparin Effectively Prevents Post-Operative Tissue Adhesions. ACS Biomaterials Science & Engineering, 2023, 9(6), 3618–3631.
23．Na Jia, Yunzhen Gao, Min Li, Yi Liang, Yuwen Li, Yunzhu Lin, Shiqi Huang, Qing Lin, Xun Sun, Qin He, Yuqin Yao, Ben Zhang, Zhirong Zhang, and Ling Zhang*. Metabolic reprogramming of proinflammatory macrophages by target delivered roburic acid effectively ameliorates rheumatoid arthritis symptoms. Signal Transduction and Targeted Therapy, 2023, 280(8).
24．Lin Li, Mengxing Zhang, Jing Li, Tiantian Liu, Qixue Bao, Xi Li, Jiaying Long, Leyao Fu, Zhirong Zhang, Shiqi Huang, Zhenmi Liu*, and Ling Zhang*. Cholesterol removal improves performance of a model biomimetic system to co-deliver a photothermal agent and a STING agonist for cancer immunotherapy. Nature Communications, 2023, 5111(14).
25．Tiantian Liu, Zehang Zhou, Mengxing Zhang, Puxin Lang, Jing Li, Zhenmi Liu, Zhirong Zhang, Lin Li*, and Ling Zhang*. Cuproptosis-immunotherapy using PD-1 overexpressing T cell membrane-coated nanosheets efficiently treats tumor. Journal of Controlled Release, 2023, 362: 502-512.
26．Yuan Xue, Shuting Bai, Leilei Wang, Shi Luo, Zhirong Zhang, Tao Gong and Ling Zhang*. A dual-responsive nanoplatform with feedback amplification improves antitumor efficacy of photodynamic therapy. Nanoscale, 2022, 14(7): 2758-2770.
27．Shiqi Huang, Lang Deng, Hanming Zhang, Luyao Wang, Yicong Zhang, Qing Lin, Tao Gong, Xun Sun, Zhirong Zhang*, and Ling Zhang*. Co-delivery of TRAIL and paclitaxel by fibronectin-targeting liposomal nanodisk for effective lung melanoma metastasis treatment. Nano Research, 2022, 15(1): 728-737.
28．Qingsi Wu, Jiading Wang, Yuanfang Wang, Ling Xiang, Yulu Tan, Jiaxing Feng, Zhirong Zhang, and Ling Zhang*. Targeted delivery of celastrol to glomerular endothelium and podocytes for chronic kidney disease treatment. Nano research, 2022, 15(4): 3556-3568.
29．Xiaomin Xu, Yani Xu, Yuai Li, Min Li, Leilei Wang, Qiang Zhang, Bingjie Zhou, Qing Lin, Tao Gong, Xun Sun, Zhirong Zhang*, and Ling Zhang*. Glucose-responsive erythrocyte-bound nanoparticles for continuously modulated insulin release. Nano Research, 2022, 15(6): 5205-5215.
30．Min Li, Xiaomin Xu, Rongying Shi, Yuai Li, Qing Lin, Tao Gong, Xun Sun, Zhirong Zhang, and Ling Zhang*. Smart erythrocyte-hitchhiking insulin delivery system for prolonged automatic blood glucose control. Biomaterials Science, 2022, 10(10): 2638-2649.
31．Lan Yang, Yongshun Zhang, Yu Zhang, Yani Xu, Yuai Li, Zhiqiang Xie, Hairui Wang, Yunzhu Lin, Qing Lin, Tao Gong, Xun Sun, Zhirong Zhang, and Ling Zhang*. Live Macrophage-Delivered Doxorubicin-Loaded Liposomes Effectively Treat Triple-Negative Breast Cancer. ACS nano, 2022, 16(6): 9799-9809.
32．Lan Yang, Shiqi Huang, Zhirong Zhang, Zhenmi Liu, and Ling Zhang*. Roles and Applications of Red Blood Cell-Derived Extracellular Vesicles in Health and Diseases. International Journal of Molecular Sciences, 2022, 23(11): 5927.
33．Lin Li, Mengxing Zhang, Tiantian Liu, Jing Li, Shili Sun, Junjie Chen, Zhenmi Liu, Zhirong Zhang, and Ling Zhang*. Quercetin-ferrum nanoparticles enhance photothermal therapy by modulating the tumor immunosuppressive microenvironment. Acta Biomaterialia, 2022, 154:454-466.
34．Jiading Wang, Qingsi Wu, Yuanfang Wang, Ling Xiang, Jiaxing Feng, Zhaojie Zhou, Qiang Fu* and Ling Zhang*. Collagenase-loading pH-sensitive nanocarriers efficiently remodeled tumor stroma matrix and improved enrichment of nanomedicines. Nanoscale, 2021, 13(20): 9402-9414.
35．Honglin Xiang, Qiang Zhang, Yikun Han, Lan Yang, Yan Zhang, Qiang Liu, Zhirong Zhang*, and Ling Zhang*. Novel brain-targeting 3-n-butylphthalide prodrugs for ischemic stroke treatment. Journal of Controlled Release, 2021, 335: 498-514.
36．Lydia Wunderley1, Ling Zhang1, Rebecca Yarwood, Wenxia Qin, Martin Lowe, Philip Woodman*. Endosomal recycling tubule scission and integrin recycling involve the membrane curvature-supporting protein LITAF. Journal of cell science, 2021, 134(15): jcs258549.
37．Lang Deng, Hanming Zhang, Yu Zhang, Shi Luo, Zhengwu Du, Qing Lin, Zhirong Zhang, and Ling Zhang*. An exosome-mimicking membrane hybrid nanoplatform for targeted treatment toward Kras-mutant pancreatic carcinoma. Biomaterials Science, 2021, 9(16): 5599-5611.
38．Yuai Li, Lan Yang, Xiaomin Xu, Min Li, Yicong Zhang, Qing Lin, Tao Gong, Xun Sun, Zhirong Zhang, and Ling Zhang*. Multifunctional size-expandable nanomedicines enhance tumor accumulation and penetration for synergistic chemo-photothermal therapy. ACS Applied Materials & Interfaces, 2021, 13(39): 46361-46374.
39．Yu Fu, Leilei Wang, Wei Liu, Lan Yang, Lin Li, Luyao Wang, Xun Sun, Zhi-rong Zhang, Qing Lin*, and Ling Zhang*. OX40L blockade cellular nanovesicles for autoimmune diseases therapy. Journal of Controlled Release, 2021, 337: 557-570.
40．Yicong Zhang, Yuai Li, Shiqi Huang, Hanming Zhang, Qing Lin, Tao Gong, Xun Sun, Zhirong Zhang, Ling Zhang*. Enhanced anti-metastatic therapy with down-regulation of heparinase expression by ROS-responsive micellar nanoparticles. Nanoscale, 2021, 13(36): 15267-15277.
41．Shiqi Huang, Yining Zhu, Ling Zhang*, and Zhirong Zhang. Recent Advances in Delivery Systems for Genetic and Other Novel Vaccines. Advanced Materials, 2021: 2107946.
