张凌，男，博士，四川大学高分子科学与工程学院研究员，医用高分子材料系（生物医学工程方向）成员。参与获得国家科学技术进步奖二等奖。国家自然科学基金“优秀青年人才”项目获得者、四川省学术带头人后备人选、四川省青年人才、成都市蓉漂人才。工作主要涉及高分子与生物学交叉领域，包括材料-生物相互作用机理及后续生物效应、小体积材料的跨膜运输和信号、新型药物传递材料、新型医疗用材料、高分子及纳米材料的毒性研究等等。此外，对生物信息学、计算数学、生物物理等学科在相关研究中的应用也有浓厚兴趣。与华西医院、华西第四医院、华中同济、川大计算机、中科院植物所等多个单位开展深入合作。
近年在Adv. Mater., Nature Commun., STTT, Adv. Funct. Mater., Sci. Adv., ACS Nano等杂志上以第一作者或通讯作者发表论文50余篇。发明专利转让4项，转化总金额3000余万元；目前正积极开展医疗器械等产品的转化开发工作。
个人简介
2020年9月 至今，四川大学高分子科学与工程学院，研究员
2018年9月— 2020年8月，四川大学高分子科学与工程学院，特聘副研究员
2011年3月—2018年6月，英国曼彻斯特大学生物、医药及健康学院，博士后，合作导师：Philip Woodman教授，Victoria Allan教授，Alan Roseman博士。
2006年9月—2011年3月，英国曼彻斯特大学生命科学院，硕士及博士，导师：Philip Woodman教授，Hilary Ashe博士，Richard Kamerer博士。
2002年9月—2006年6月，复旦大学生命科学院，学士，导师：金力教授。
研究方向
1. 高分子等材料与生物系统微观相互作用
2. 脂质体及其他纳米材料递送系统
3. 微材料的跨膜运输以及跨膜信号系统
4. 结合组学、数学模型等的生物-纳米系统研究
常年招聘材料、生物、医药、数学、物理背景的研究生（包括各种联合培养形式）和博后，同时欢迎四川大学各学科背景的本科同学，以及成都地区其他院校本科生到实验室做毕业论文或利用业余时间从事科研项目。此外，我们将为课题组成员以后的留学、出国交流及保研等方面尽量提供推荐和帮助。欢迎感兴趣的同学与我直接联系。邮箱: zhangling83@scu.edu.cn地址：四川大学望江校区高分子学院主楼405。
2018年以来发表论文：
2024年:
1.Yani Xu, Lan Yang, Min Li, Haozhou Shu, Na Jia, Yunzhen Gao,Rongying Shi, Xiaojia Yang, Zhirong Zhang, and Ling Zhang*. Anti-osteosarcoma trimodal synergistic therapy using NiFe-LDH and MXene nanocomposite for enhanced biocompatibility and efficacy. Acta Pharmaceutica Sinica B, 2024, 14(3), 1329-1344.
2.Leilei Wang, Shanshan He, Rong Liu, Yuan Xue, Yuan Quan, Rongying Shi, Xueying Yang, Qing Lin, Xun Sun, Zhirong Zhang, and Ling Zhang*. A pH/ROS dual-responsive system for effective chemoimmunotherapy against melanoma via remodeling tumor immune microenvironment. Acta Pharmaceutica Sinica B, 2024.
3.Mengxing Zhang, Jing Li, Na Ji, Qixue Bao, Ningyun Sun, Hongding Rong, Xu Peng, Lan Yang,Mingxin Xie, Shanshan He, Qing Lin, Zhirong Zhang, Lin Li*, and Ling Zhang*. Reducing cholesterol level in live macrophages improves delivery performance by enhancing blood shear. Nano Letters, 2024, 24(2), 607-616.
4.Yicong Zhang, Yujia Wang, Hanming Zhang, Shiqi Huang, Yuai Li, Jiaying Long, Yikun Han, Qing Lin, Tao Gong, Xun Sun, Zhirong Zhang, and Ling Zhang*. Replacing cholesterol with asiatic acid to prolong circulation and enhance anti-metastatic effects of non-PEGylated liposomes. Journal of Controlled Release, 2024, 366, 585-595.
2023年:
1.Shiqi Huang, Hanming Zhang, Yicong Zhang, Luyao Wang, Zhirong Zhang, and Ling Zhang*. Comparison of two methods for tumour-targeting peptide modification of liposomes. Acta Pharmacologica Sinica, 2023, 44(4): 832-840.
2.Qiang Zhang, Yikun Han, Honglin Xiang, Min Li, Lan Yang, Qiang Liu, Yan Zhang, Zhirong Zhang, Qing Lin*, and Ling Zhang*. Biopharmaceutical, preclinical pharmacokinetic and pharmaco-dynamic investigations of an orally administered novel 3-nbutylphthalide prodrug. European Journal of Pharmaceutical Sciences, 2023,180: 106308.
3.Puxin Lang, Tiantian Liu, Shiqi Huang, Zhaojie Zhou, Mengxing Zhang, Yunzhu Lin, Qin He, Yuqin Yao, Zhenmi Liu*, and Ling Zhang*. Degradable Temperature-Sensitive Hydrogel Loaded with Heparin Effectively Prevents Post-Operative Tissue Adhesions. ACS Biomaterials Science & Engineering, 2023, 9(6), 3618–3631.
4.Na Jia, Yunzhen Gao, Min Li, Yi Liang, Yuwen Li, Yunzhu Lin, Shiqi Huang, Qing Lin, Xun Sun, Qin He, Yuqin Yao, Ben Zhang, Zhirong Zhang, and Ling Zhang*. Metabolic reprogramming of proinflammatory macrophages by target delivered roburic acid effectively ameliorates rheumatoid arthritis symptoms. Signal Transduction and Targeted Therapy, 2023, 280(8).
5.Lin Li, Mengxing Zhang, Jing Li, Tiantian Liu, Qixue Bao, Xi Li, Jiaying Long, Leyao Fu, Zhirong Zhang, Shiqi Huang, Zhenmi Liu*, and Ling Zhang*. Cholesterol removal improves performance of a model biomimetic system to co-deliver a photothermal agent and a STING agonist for cancer immunotherapy. Nature Communications, 2023, 5111(14).
6.Tiantian Liu, Zehang Zhou, Mengxing Zhang, Puxin Lang, Jing Li, Zhenmi Liu, Zhirong Zhang, Lin Li*, and Ling Zhang*. Cuproptosis-immunotherapy using PD-1 overexpressing T cell membrane-coated nanosheets efficiently treats tumor. Journal of Controlled Release, 2023, 362: 502-512.
2022年：
1.Yuan Xue, Shuting Bai, Leilei Wang, Shi Luo, Zhirong Zhang, Tao Gong and Ling Zhang*. A dual-responsive nanoplatform with feedback amplification improves antitumor efficacy of photodynamic therapy. Nanoscale, 2022, 14(7): 2758-2770.
2.Shiqi Huang, Lang Deng, Hanming Zhang, Luyao Wang, Yicong Zhang, Qing Lin, Tao Gong, Xun Sun, Zhirong Zhang*, and Ling Zhang*. Co-delivery of TRAIL and paclitaxel by fibronectin-targeting liposomal nanodisk for effective lung melanoma metastasis treatment. Nano Research, 2022, 15(1): 728-737.
3.Qingsi Wu, Jiading Wang, Yuanfang Wang, Ling Xiang, Yulu Tan, Jiaxing Feng, Zhirong Zhang, and Ling Zhang*. Targeted delivery of celastrol to glomerular endothelium and podocytes for chronic kidney disease treatment. Nano research, 2022, 15(4): 3556-3568.
4.Xiaomin Xu, Yani Xu, Yuai Li, Min Li, Leilei Wang, Qiang Zhang, Bingjie Zhou, Qing Lin, Tao Gong, Xun Sun, Zhirong Zhang*, and Ling Zhang*. Glucose-responsive erythrocyte-bound nanoparticles for continuously modulated insulin release. Nano Research, 2022, 15(6): 5205-5215.
5.Min Li, Xiaomin Xu, Rongying Shi, Yuai Li, Qing Lin, Tao Gong, Xun Sun, Zhirong Zhang, and Ling Zhang*. Smart erythrocyte-hitchhiking insulin delivery system for prolonged automatic blood glucose control. Biomaterials Science, 2022, 10(10): 2638-2649.
6.Lan Yang, Yongshun Zhang, Yu Zhang, Yani Xu, Yuai Li, Zhiqiang Xie, Hairui Wang, Yunzhu Lin, Qing Lin, Tao Gong, Xun Sun, Zhirong Zhang, and Ling Zhang*. Live Macrophage-Delivered Doxorubicin-Loaded Liposomes Effectively Treat Triple-Negative Breast Cancer. ACS nano, 2022, 16(6): 9799-9809.
7.Lan Yang, Shiqi Huang, Zhirong Zhang, Zhenmi Liu, and Ling Zhang*. Roles and Applications of Red Blood Cell-Derived Extracellular Vesicles in Health and Diseases. International Journal of Molecular Sciences, 2022, 23(11): 5927.
8.Lin Li, Mengxing Zhang, Tiantian Liu, Jing Li, Shili Sun, Junjie Chen, Zhenmi Liu, Zhirong Zhang, and Ling Zhang*. Quercetin-ferrum nanoparticles enhance photothermal therapy by modulating the tumor immunosuppressive microenvironment. Acta Biomaterialia, 2022, 154:454-466.
2021年：
1.Jiading Wang, Qingsi Wu, Yuanfang Wang, Ling Xiang, Jiaxing Feng, Zhaojie Zhou, Qiang Fu* and Ling Zhang*. Collagenase-loading pH-sensitive nanocarriers efficiently remodeled tumor stroma matrix and improved enrichment of nanomedicines. Nanoscale, 2021, 13(20): 9402-9414.
2.Honglin Xiang, Qiang Zhang, Yikun Han, Lan Yang, Yan Zhang, Qiang Liu, Zhirong Zhang*, and Ling Zhang*. Novel brain-targeting 3-n-butylphthalide prodrugs for ischemic stroke treatment. Journal of Controlled Release, 2021, 335: 498-514.
3.Lydia Wunderley1, Ling Zhang1, Rebecca Yarwood, Wenxia Qin, Martin Lowe, Philip Woodman*. Endosomal recycling tubule scission and integrin recycling involve the membrane curvature-supporting protein LITAF. Journal of cell science, 2021, 134(15): jcs258549.
4.Lang Deng, Hanming Zhang, Yu Zhang, Shi Luo, Zhengwu Du, Qing Lin, Zhirong Zhang, and Ling Zhang*. An exosome-mimicking membrane hybrid nanoplatform for targeted treatment toward Kras-mutant pancreatic carcinoma. Biomaterials Science, 2021, 9(16): 5599-5611.
5.Yuai Li, Lan Yang, Xiaomin Xu, Min Li, Yicong Zhang, Qing Lin, Tao Gong, Xun Sun, Zhirong Zhang, and Ling Zhang*. Multifunctional size-expandable nanomedicines enhance tumor accumulation and penetration for synergistic chemo-photothermal therapy. ACS Applied Materials & Interfaces, 2021, 13(39): 46361-46374.
6.Yu Fu, Leilei Wang, Wei Liu, Lan Yang, Lin Li, Luyao Wang, Xun Sun, Zhi-rong Zhang, Qing Lin*, and Ling Zhang*. OX40L blockade cellular nanovesicles for autoimmune diseases therapy. Journal of Controlled Release, 2021, 337: 557-570.
7.Yicong Zhang, Yuai Li, Shiqi Huang, Hanming Zhang, Qing Lin, Tao Gong, Xun Sun, Zhirong Zhang, Ling Zhang*. Enhanced anti-metastatic therapy with down-regulation of heparinase expression by ROS-responsive micellar nanoparticles. Nanoscale, 2021, 13(36): 15267-15277.
8.Shiqi Huang, Yining Zhu, Ling Zhang*, and Zhirong Zhang. Recent Advances in Delivery Systems for Genetic and Other Novel Vaccines. Advanced Materials, 2021: 2107946.
2020年：
1.Yu Fu, Qing Lin, Zhirong Zhang*, and Ling Zhang*. Therapeutic strategies for the costimulatory molecule OX40 in T-cell mediated immunity. Acta pharmaceutica Sinica B, 2020,10(3):414-433.
2.Yuanfang Wang, Qingsi Wu, Jiading Wang, Lin Li, Xun Sun, Zhirong Zhang, and Ling Zhang*. Co-delivery of p38α MAPK and p65 siRNA by Novel Liposomal Glomerulus-Targeting Nano Carriers For Effective Immunoglobulin A nephropathy Treatment. Journal of Controlled Release, 2020, 320: 457-468.
3.Wei Liu, Qing Lin, Yu Fu, Shiqi Huang, Chengqi Guo, Lin Li, Leilei Wang, Zhirong Zhang, and Zhang Ling*. Target Delivering Paclitaxel by Ferritin Heavy Chain Nanocages for Glioma Treatment. Journal of Controlled Release, 2020, 323：191-202.
4.Shiqi Huang, Yicong Zhang, Luyao Wang, Wei Liu, Linyu Xiao, Qing Lin, Tao Gong, Xun Sun, Qin He, Zhirong Zhang, and Zhang Ling*. Improved Melanoma Suppression with Target-delivered TRAIL and Paclitaxel by a multifunctional Nanocarrier. Journal of Controlled Release, 2020,325:10-24.
5.Xiaoyu Hong, Xiaofang Zhong, Guangsheng Du, Yingying Hou, Yunting Zhang, Zhirong Zhang, Tao Gong, Ling Zhang*, and Xun Sun*. The pore size of mesoporous silica nanoparticles regulates their antigen delivery efficiency. Science Advances, 2020, 6(25): eaaz4462.
6.Yingying Hou, Ying Wang, Yao Tang, Zixuan Zhou, Lu Tan, Tao Gong, Ling Zhang*, and Xun Sun*. Co-delivery of antigen and dual adjuvants by aluminum hydroxide nanoparticles for enhanced immune responses. Journal of Controlled Release, 2020, 326(10):120-130.
7.Yaxian Zheng, Liyun Xing, Liqiang Chen, Rui Zhou, Jiawei Wu, Xi Zhu, Lian Li, Yucheng Xiang, Ruinan Wu, Ling Zhang*, and Yuan Huang*. Tailored Elasticity Combined with Biomimetic Surface Promotes Nanoparticle Transcytosis to Overcome Mucosal Epithelial Barrier. Biomaterials, 2020, 262: 120323.
2019年：
1.Sha Li, Yingchun Zeng, Ke Peng, Chang Liu, Xinyi Wang, Qing Lin, Tao Gong, Xun Sun, Zhirong Zhang, and Ling Zhang*. Design and evaluation of glomerulus mesangium-targeted PEG-PLGA nanoparticles loaded with dexamethasone acetate. Acta Pharmacologica Sinca, 2019, 40(1): 143-150.
2.Luyao Wang, Bingjie Zhou, Shiqi Huang, Mengke Qu, Qing Lin, Xun Sun, Tao Gong, Yuan Huang, Qin He, Zhirong Zhang, and Ling Zhang*. Novel fibronectin-targeted nanodisk drug delivery system displayed superior efficacy against prostate cancer compared with nanospheres. Nano Research, 2019, 12(10): 2451-2459.
3.Qing Lin, Mengke Qu, Hirak K Patra, Shanshan He, Luyao Wang, Xun Hu, Linyu Xiao, Yu Fu, Tao Gong, Qin He, Ling Zhang*, Xun Sun, and Zhirong Zhang. Exosome-like nanoplatform modified with targeting ligand improves anti-cancer and anti-inflammation effects of Imperialine. Journal of Controlled Release, 2019, 311-312:104-116.
4.Lin Li, Shili Sun, Lingli Tan, Yuanfang Wang, Luyao Wang, Zhirong Zhang, and Ling Zhang*. Polystyrene nanoparticles reduced ROS and inhibited ferroptosis by triggering lysosome stress and TFEB nucleus translocation in a size-dependent manner. Nano Letters, 2019, 19(11): 7781-7792.
5.Qing Lin, Mengke Qu, Hirak K. Patra, Shanshan He, Luyao Wang, Xun Hu, Linyu Xiao, Yu Fu, Tao Gong, Qin He, Ling Zhang*, Xun Sun, and Zhirong Zhang. Mechanistic and therapeutic study of novel anti-tumor function of natural compound imperialine for treating non-small cell lung cancer. Journal Ethnopharmacology, 2019, 247: 112283.
2018年：
1.Mengke Qu, Qing Lin, Shanshan He, Luyao Wang,Yao Fu, Zhirong Zhang*, and Ling Zhang*. A brain targeting functionalized liposomes of the dopamine derivative N-3,4-bis(pivaloyloxy)-dopamine for treatment of Parkinson's disease. Journal of Controlled Release, 2018, 277: 173-182.
2.Luyao Wang, Mengke Qu, Shiqi Huang, Liuqing Yang, Zhirong Zhang, Qing Lin*, and Ling Zhang*. A Novel α-Enolase-targeted Drug Delivery System for High -efficacy Prostate Cancer Therapy. Nanoscale, 2018, 10(28): 13673-13683.
3.Yu Fu, Wei Liu, Luyao Wang, Biyue Zhu, Mengke Qu, Liuqing Yang, Xun Sun, Tao Gong, Zhirong Zhang, Qing Lin*, and Ling Zhang*. Erythrocyte- membrane-camouflaged nanoplatform for seamless glucose-responsive insulin deliverywith enhanced circulation. Advanced Functional Materials, 2018, 28(41): 1802250.
4.Mengke Qu, Qing Lin, Luyi Huang, Yao Fu, Luyao Wang, Shanshan He, Yu Fu, Shengyong Yang, Zhirong Zhang, Ling Zhang*, and Xun Sun*. Dopamine-loaded blood exosomes targeted to brain for better treatment of Parkinson's disease. Journal of Controlled Release, 2018, 287: 156-166.
5.Shanshan He, Qing Lin, Mengke Qu, linyu Xiao, Lang Deng, Zhirong Zhang, and Ling Zhang*, Liver-targeted co-delivery of entecavir and glycyrrhetinic acid based on albumin nanoparticle to enhance the accumulation of entecavir. Molecular Pharmaceutics, 2018, 15(9): 3953-3961.
